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Overview of Hazardous Environmental Contaminant Pcbs In Human Cancer: Potential Contributions of Carcinogenesis
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| Author:
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FATEMEH YAZDI, MOHAMMAD HOSSEIN YAZDI, AKRAM EIDI, SHAHRAM SHOEIBI
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| Abstract:
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Polychlorinated biphenyls (PCBs) are a mixture of 209 different chlorinated biphenyl congeners (forms), 36 of which are environmentally relevant. Due to both lipid solubility and the absence of an adequate metabolic pathway in the organisms, PCBs tend to bioaccumulate in the trophic chains. The feed has been evaluated in several studies as a major way of PCB exposure to farm animals and human exposure to PCBs through the consumption of seafood, meat, milk, and eggs. This review contains Physicochemical possessions, metabolism and excretion, Methods of detection and quantification, Toxicology, Carcinogenic Effects, and mechanism of PCBs. Investigations indicated that changes in polymorphism and the expression of a particular gene, besides the exposure to PCBs, could cause progressive variations in the development of some forms of cancer. In conclusion, the existing review sheds some light on the effects of a number of PCBs on the development of some types of cancer while offering a number of reasons for the negative contribution of exposure to PCBs to the incidence of cancer.
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| Keyword:
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Polychlorinated biphenyls, Carcinogenicity, Toxicology, Human Health.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.738
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| Download:
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Request For Article
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