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Hepatoprotective Potential of Methanolic and Aqueous Leaves Extracts of Swietenia Mahagoni Linn in Paracetamol and CCl4 induced Hepatotoxicity Models
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| Author:
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KOLA VENU, LAXMAIAH CH, DIPTENDU BHOWMIK, SANTHOSH KUMAR CHINNAIYAN, CHIRANJIB BHATTACHARJEE
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| Abstract:
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The present research was performed to estimate both the phytochemistry and pharmacological potential of
Swietenia mahagoni leaves in validated animal models. The shade dried and powdered leaves were extracted with
different organic solvents and after successive extraction, the aqueous extract was subjected to preliminary
phytochemical study for identification of various phytochemicals. The fixed-dose method for acute toxicity was
performed following the OECD guidelines 420. The hepatoprotective property of the aqueous and methanolic
extracts was studied against paracetamol and carbon tetrachloride models in rats. Groups that are treated with
aqueous, methanolic extracts and Silymarin depicted an important restoration of wet liver volume and weight
near to its normal conditions. Toxic effects produced by carbon tetrachloride and paracetamol were significantly
controlled with both the extracts by restoration of levels of the biochemistry of liver function, with that of
standard silymarin. The toxicant decreased Catalase and SOD activities of the liver. The histopathological
changes like necrosis, and fatty changes (steatosis), etc were fully or partly prevented in treated animals using
extract. The results are due to the presence of flavonoids, alkaloids, saponins, steroids, tannins, and glycosides
in both the extracts are responsible for hepatoprotective activity. A dose-dependent hepatoprotective effect
was produced with both the extracts.
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| Keyword:
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Swietenia mahagoni, Hepatoprotective, Silymarin, Paracetamol, Carbon Tetrachloride
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.071
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| Download:
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