|
|
|
|
|
|
Article Detail
|
|
Label
|
|
|
Label
|
|
|
|
A Study on Hepatoprotective Activity of Bark Extracts of Bassia latifolia in Paracetamol and Carbon Tetra Chloride Induced Hepatoxicity Models in Rats
|
|
| Author:
|
CHINTHALA SRILEKHA, GUDAS GANESH KUMAR, DIPTENDU BHOWMIK, SHAHJALAL ALAM, GANDRA SINDHU, GOURAVELLY AKANKSHA, CHAMAKURI SUBBA RAO, KOTHA ANITHA, ANIKHA MEHVISH, KOLA VENU
|
| Abstract:
|
Objectives: To study the hepatoprotective activity of bark extracts of Bassia latifolia (Sapotaceae) in PCM and
ALC (Curative method) induced hepatotoxicity in rats.
Background: In literature plant Bassia latifolia is widely mentioned for its uses in ulcers, fractures, bronchitis,
ear complaints, expelling worms from the body and in orchitis. In literature the plant is mentioned for its use in
congestion of liver/biliousness. Furthermore, availability of any scientific data is absent on this plant’s bark
extracts’ hepatoprotective activity. Therefore, the current study aimed in exploring this plant’s bark extracts’
hepatoprotective activity in different hepatotoxic models as mentioned above in rats.
Materials and methods: Hepatoprotective activity of this plant’s bark extracts was evaluated against ALC and
PCM (curative aspect) stimulated hepatotoxicity model in rats, as well as Standard drug such as Silymarin was
utilized as recommendation in every model.
Results: Preliminary phytochemical studies with AEBBL and AQEBBL showed that in both the extracts
phytoconstituents like flavonoids, triterpenoids, saponins, tannins and glycosides are present. On subjecting these
2 extracts for LD50 analyses, it has been observed that both the extracts does not resulted in mortality or any
abnormal behavior even at the 2000mg/Kg dose level/body weight in mice. 3 distictive doses such as low 1/20th
(100 mg/Kg), medium1/10th (200 mg/Kg) as well as high 1/5th (400 mg/Kg) doses from the maximum dose tested
for LD50 were chosen for the current analysis. Silymarin, AEBBL and AQEBBL treated groups when compared
to PCM and ALC (curative aspect) induced hepatotoxic rats the increased TST, TG, CHO, BILT, BILD, ALP,
AST, ALT levels, wet liver volume, and wet liver weight were considerably reduced and there was significant
increase in PRO and ALB levels. Also, there was fully or partial prevention of histo-pathological changes that are
necrosis, fatty changes (steatosis) etc.
Conclusion: The present study on hepatoprotective activity with AEBBL and AQEBBL confirmed the above
mentioned effect because of several phytoconstituents like triterpenoids and flavonoids as these were already
reported for their hepatoprotective activity.
|
| Keyword:
|
Bassia latifolia (Roxb), Bark, paracetamol, alcohol , silymarin. Hepatoprotective.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.03.074
|
| Download:
|
Request For Article
|
|
|
|
|
|
|
|
|
|
|