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Results of Studying the Effect of Ecdysterone as the Main Representative of Phytoexdysteroids to the Resistance of Experimental Animals to Destabilizing Factors of the Environment
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| Author:
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SYROV V N, KHUSHBAKTOVA Z A, SHAKHMUROVA G A
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| Abstract:
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The effect of ecdysterone, one of the most widespread phytoecdysteroids in the plant world, has been investigated on its ability to increase the general nonspecific resistance of the organism to a wide range of destabilizing environmental factors. It was found that the introduction of ecdysterone to animals prevents the involution of the thymic-lymphatic system, hypertrophy of the adrenal glands, ulceration on the gastric mucosa during acute stress in rats, caused by their 24-hour immobilization in the supine position. Ecdysterone increases the physical performance of animals (swimming to the limit, has a protective effect on the body in case of poisoning with ethanol, sodium nitroprusside, sarcolysin, and radioactive irradiation. activity. The effect of ecdysterone, one of the most widespread phytoecdysteroids in the plant world, has been investigated on its ability to increase the general nonspecific resistance of the organism to a wide range of destabilizing environmental factors. It was found that the introduction of ecdysterone to animals prevents the involution of the thymic-lymphatic system, hypertrophy of the adrenal glands, ulceration on the gastric mucosa during acute stress in rats caused by their 24-hour immobilization in the supine position. Ecdysterone increases the physical performance of animals (swimming to the limit, has a protective effect to the organism in case of poisoning with ethanol, sodium nitroprusside, sarcolysin, and with radioactive irradiation. In all carried out experiments, ecdysterone acted similarly to the well-known preparation with an adaptogenic type of action – extact of Eleutherococcus, but it showed more pronounced activity.
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| Keyword:
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Phytoecdysteroids, ecdysterone, general non-specific resistance of organism, adaptogenic action.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.046
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| Download:
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