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Development and Characterisation of Acetyl Salicylic Acid – Argenine Co-Crystals for Improved Dissolution
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| Author:
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, JAYAPRAKASH H V, SHANTHALA H K
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| Abstract:
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BCS class II drugs have limitation of being water insoluble, hence is less bioavailable. Safety and efficacy of the drug affected by bioactive availability and stability. Active Pharmaceutical Ingredient with excipient co-crystallisation is found to be promising one for not only increasing the solubility but also rate of dissolution and stability. The present work is to co-crystallise Acetyl Salicylic acid (ASA) with Argenine by solvent evaporation. The obtained co-crystals were subjected to physicochemical characterization by FTIR, PXRD, m.pt, SEM, and dissolution study at pH 4 was done. The study showed that Acetyl Salicylic Acid - Argenine co-crystal formed with stability and was having more dissolution rate.
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| Keyword:
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Dissolution, bioavailability, Argenine, acetyl Salicylic Acid, cocrystal.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.040
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| Download:
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