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Development and Evaluation of Nanosponges as Oral Delivery System for Ramipril "
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| Author:
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, AHMED MAJEED MOUSA, ZUHEIR OSMAN, ABUBAKR O. NUR
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| Abstract:
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Ramipril is potent ACE inhibitors long acting available clinically ordered once every day , using to treatment the heart failure and all types of hypertension but the poor solubility restricts its application and function. As a result, the objective of this study in attempt to solve the above restrictions , was to encapsulate the ramipril by ß-cyclodextrin – based nanosponges (NS).
To produce nanosponges , diphenyl carbonate was cross-linked in various molar ratios with ß-cyclodextrin 1:2, 1:3, 1:4, and 1:5. The freeze-drying process was used to load ramipril (RAM) onto plain nanosponge . The results showed the nanosponges' particle sizes were ranged from 163.9 to643.4 nm, with a low polydispersity index. The
solubilisation of RAM has also been monitored and found to be reinforced by 2.56 folds with the ß-CDNS1:3 in distilled water. In addition, for characterization of nanosponges RAM the zeta potential and X-ray diffraction were performed. Spectral analytical results showed the creation of inclusion complexes.
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| Keyword:
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Ramipril , Beta cyclodextrin , nanosponge, solubilisation efficiency and microscopic study .
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.012
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| Download:
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