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Formulation and Evaluation of Dexromethorpthan Chocolate for Pediatrics
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| Author:
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SACHIN GHOLVE, DHANASHREE CHANDAK, NARSING KEDAR, OMPRAKASH BHUSNURE
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| Abstract:
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Chocolate is an anhydrous medium which resistant to microbial growth and to hydrolysis of water-sensitive
active agent. Chocolate abundantly contains saturated fat, polyphenols, sterols, di and triterpenes, aliphatic
alcohols, methylxanthines, flavanols and antioxidant cocoa. Chocolate drug delivery system has advantage that
includes a possible bypass of first-pass effects and avoidance of pre-systematic elimination within the GI tract.
The objective of the present study is to develop a palatable chocolate formulation of Dextromethorphan
hydrobromide for pediatric administration using Qbd approach. The first generation antihistamine
dextromethorphan is classified as an antitussive by the United States Food and Drug Administration to inhibit
cough reflex sensitivity in subjects with pathological cough. In present work, firstly chocolate base is prepared
by using cocoa butter, cocoa powder, lecithin and pharmaceutical grade sugar. Then therapeutic drug is
incorporated to prepared chocolate base. The prepared medicated chocolate is evaluated for appearance,
moisture content, in-vitro drug release, blooming test, drug content determination and drug excipients
compatibility by FIIR Spectroscopy. The drug release from chocolate shows First order kinetics and diffusion
mechanism. Among all formulations the formulation F5 showed complete release of DXM with 98.77% at the
end of 1 hour. The prepared formulations has no drug excipient interactions and there has no degradation in
drug. It is stable during chocolate formulation preparation.
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| Keyword:
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Chocolate, Medicated Chocolate, In vitro drug release, Pediatrics.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.471
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| Download:
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