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Synthesis, Characterization, Antimicrobial, AntiInflammatory and Anti-Diabetic Activity Studies on Metal (II) Complexes Derived from 4-(2-AMINO ETHYL) BENZENE-1, 2-DIOL and BUTANE-2, 3-DIONE
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| Author:
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T GOMATHI, S KARTHIK, S VEDANAYAKI
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| Abstract:
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A novel Schiff base ligand (L) was synthesized using 4-(2-amino ethyl) benzene-1, 2-diol (Dopamine) and butane
- 2, 3-dione. Co(II), Ni(II), Cu(II) and Zn(II) complexes with this hexadentate ligand were synthesized with
metal: ligand stoichiometry 1:1. The Schiff base ligand and its metal complexes have been characterized by
elemental analysis, molar conductance, magnetic susceptibility, IR, electronic spectra, ESR, NMR, Mass spectra
and SEM studies. Molar conductance showed that all complexes are non-electrolytic nature. Different
morphologies of synthesized compounds were identified by SEM images. Schiff base ligand and its metal
complexes were screened against gram-positive bacteria, gram-negative bacteria and one fungus strain. The
data shows that the ligand and its metal complexes have significant activity. Copper(II) complex shows better
activity than other complexes. The Schiff base ligand and its copper(II) complex were evaluated for the antiinflammatory by HRBC membrane stabilization method. The anti-diabetic activity of Schiff base ligand and its
copper(II) complex was also studied by the Alpha-amylase method
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| Keyword:
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Schiff base, molar conductance, ESR, anti-diabetic
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.004
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| Download:
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