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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Gliclazide Tablet Loaded with Nano Sponges

Author: D SHRUTHIKA REDDY, K LATHA, NASEEB BASHA SHAIK, RUSHDA PARVEEN, AKHILA RAMIREDDY, HANISH SAI GOPISHETTY
Abstract: The aim of this study was to design gliclazide tablets loaded with nanosponges, a BCS Class II drug with pH dependent solubility. Nanosponges are particles with a nanosize range which is poorly water soluble drug and provides prolong release with reduced side effects. The sustained release tablets were designed such that the nanosponges were first optimised and then compressed into tablets. The nanosponges were subjected for flow properties like angle of repose, Hausner’s ratio and compressibility index. The nanosponges were optimized for parameters like surface morphology, entrapment efficiency and in-vitro drug release. The required sustaining property was obtained with 1.5% ethyl cellulose & 1% PVA (GN16) showing zero order kinetics and Higuchi mechanism having “n” value of 1.317 indicating super case-II transport due to relaxation of polymer chain and diffusion. The optimized nanosponges were compressed into tablets by direct compression using different anti caking agents and evaluated for physicochemical properties and in-vitro drug release. The anticaking agents are used to maintain the morphology of the nanosponges which help in retaining the properties of nanosponges. The optimization for order of release was maintained zero from nanosponges to tablet preparation whereas mechanism of transport was anomalous which was found from the ‘n’ values as 0.527 (GNT7) and 0.594 (GNT10). Among all the formulations of nanosponges, formulation GN16 was optimized which showed nanosize range of 0.298- 0.813 µm through SEM and 98.29% drug release in 24 hrs and were stable under storage conditions. Gliclazide tablets loaded with nanosponges have been formulated to increase its efficacy of sustained release and thereby improving its solubility.
Keyword: Gliclazide, Nanosponges; Ethyl cellulose, PVA and Direct compression method
DOI: https://doi.org/10.31838/ijpr/2021.13.02.500
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