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Comparative Study of Paclitaxel Solid Dispersions
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| Author:
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SYEDA SHABANA SULTANA, DR.K.APPANNA CHOWDARY, DR.SUMER SINGH
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| Abstract:
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Objective: The present study aimed to increase the solubility of an anticancer agent Paclitaxel by using different solubility enhancement techniques. Paclitaxel has poor aqueous solubility results in decreased bioavailability and insufficient therapeutic effect.
Methods: In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug Paclitaxel by lipid-solid dispersions, liquisolid compacts, hydrotropy method and loaded solid dispersion methods. Compatibility between drug and excipients examined by Fourier Transform Infrared spectroscopy and Differential Scanning Calorimetry studies.
Results: By performing comparative study precompression studies revealed solid dispersions prepared by hydrotropy method was shown best fit. From the dissolution study, it is observed that the dissolution rate of Paclitaxel is low because only 29.33% of drug dissolved in 60 minutes and all solid dispersions batches showed significantly enhanced dissolution rate of 37.45-66.54% in 60 minutes.
Conclusion: Greatest improvement in a dissolution rate was observed in Hydrotropy method of solid dispersion.
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| Keyword:
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Paclitaxel, solubility, lipid-solid dispersions, liquisolid compacts, hydrotropy
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.477
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| Download:
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