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Association of genetic polymorphism in adiponectin and adiponectin receptor genes with type II diabetes mellitus in patients of rural south-western Maharashtra
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| Author:
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PRATIK P.DURGAWALE, KAILAS D.DATKHILE, VIRENDRA C.PATIL, VASANT V.DEVKAR, SARJERAO A.DABANE, VIJAYKUMAR S.WADER, SATISH V.KAKADE
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| Abstract:
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Adiponectin is one of the most important adipokines secreted by differentiated adipocytes, involved in regulation of fatty acid oxidation and influences insulin secretion in pancreatic cells. It is thus an important link in obesity, insulin resistance, and type II diabetes mellitus. It signals cells by binding to adiponectin receptors 1 and 2 which are expressed in all types of cells including liver, pancreas, skeletal muscles, etc. Lower expression or mutations in these genes have been linked to insulin resistance-like symptoms. In the present study, adiponectin SNP rs2241766, and ADIPOR1 rs22753738 and ADIPOR2 rs16928751 were investigated using polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) in obese and non-obese diabetic patients from rural south-western Maharashtra. We found that adiponectin SNP rs2241766 may be negatively associated with development of T2DM among non-obese individuals (OR 0.316(0.156-0.638), p = 0.016); while adiponectin receptor 2 SNP rs16928751 may be negatively associated with T2DM among obese diabetic individuals (OR 0.042(0.0024-0.719), p = 0.004). Adiponectin recptor 1 SNP rs22753738 may not be associated with T2DM among the studied population.
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| Keyword:
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Adiponectin; Adiponectin Receptor 1; Adiponectin Receptor 2; T2DM.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.495
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