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A Review on Anti-tumor activity of Curcuma longa
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| Author:
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M.VASUKI , D.GAYATHRI, B.NAGA PUSHPA, MANISHA DAS, S.DEVISHREE, K.V.BHASKARA RAO
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| Abstract:
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Curcuma longa is commonly known as turmeric, which was considered an indispensable part of Indian Ayurvedic in the last 4000 years because of its medicinal and therapeutic properties. The rhizome of Curcuma longa contains a yellow pigment known as curcuminoids with the major constituent of curcumin (75-80%), demethoxycurcumin (10-15%) and bisdemethoxycurcumin (5%). It has been extensively used because it is non-toxic and exhibits various therapeutic properties like antitumor, anti-inflammatory, antioxidant and many more. Curcumin acts as a powerful antioxidant by protecting healthy cells from the formation of a tumor. The effect of Curcumin rapidly gets increased when it is used with analogous. It has been demonstrated that it possesses the antitumor property in several cell lines such as breast, ovarian and melanoma cells. Several research studies are being carried out to know the potential of curcumin analogs. It plays an important role by inducing programmed cell death i.e., apoptosis in the site of tumor formed cells. This is achieved by inhibiting several cellular pathways and as well as proteins and enzymes. One such pathway is the NF-kB signaling pathway in which Curcumin effectively inhibits Nuclear factor Kappa B molecule by turning on the gene of inflammation. This review focuses on the role of turmeric as an active bioactive substance that fights against inflammation especially at chronic inflammations.
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| Keyword:
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Turmeric, Cancer, Anti-tumor, NF-kB pathway, Antioxidant, Cyclo-Oxygenase2.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.491
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| Download:
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