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Evaluation and Optimization on Developed Transdermal Patch of Domperidone Formulation
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| Author:
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SEKAR AYU PAWESTRI, AKHMAD KHARIS NUGROHO, ENDANG LUKITANINGSIH, PURWANTININGSIH
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| Abstract:
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Domperidone, an antiemetic drug, has a low oral bioavailability. Nausea-vomiting conditions, especially in pediatrics, need a convenient and effective administration manner. A transdermal patch is a dosage form attached to the skin non-invasively, circumventing the first-pass effect and giving practical administration. Optimization of the developed pharmaceutical formulations is an important step to obtaining the patch's desired physical properties. The purposes of this study were: 1) to formulate domperidone into patch dosage form with the variation of oleic acid and isopropyl alcohol as an enhancer, 2) to understand the effect of various concentrations of enhancer on the physical properties, and 3) to determine the optimum formula composition of the patch. The optimization of the patch was performed based on the Simplex-Lattice-Design method using Design-Expert version 10 software. Evaluations of the patch's physical characteristics were based on parameters of weight variation, patch thickness, folding endurance, moisture content, moisture uptake, and content uniformity. The results indicate that olei acid and isopropyl alcohol concentrations' variation influenced weight variation, patch thickness, and content uniformity. Meanwhile, such compositions do not influence moisture content, moisture uptake, and folding endurance. Oleic acid has a dominant effect on weight, thickness, and moisture uptake. Meanwhile, isopropyl alcohol has a dominant impact on moisture content and content uniformity. The optimum formula was 1,25% of oleic acid and 17,5% of isopropyl alcohol in the formula of the patch. The drug release mechanism of the optimum formula followed the zero order model.
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| Keyword:
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domperidone, transdermal patch, oleic acid, isopropyl alcohol, optimization.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.195
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| Download:
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