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Preferential Effect of Loxoprofen in Lipopolysaccharide Induced Immobility-Time in Forced Swim Test in Mice
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| Author:
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KUNDU SMITA S, DIGVIJAYSINH G RANA
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| Abstract:
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Objective: The objective of the present study was to evaluate the effect of Loxoprofen in forced swim test
model of depression in mice.
Background: It has been reported that there is an abnormal prostaglandin E levels in depression. It has been
reported in various clinical studies and preclinical studies that there has been an elevated levels of
prostaglandins (PGs) specifically prostaglandin E2 (PGE2) in depression.
Method: There was a measurement of immobility time in forced swim test (FST) in which mice were
subjected to the treatment of Loxoprofen (16.8 mg/kg, p.o.). The same drug treatment was given 60 min
before Lipopolysaccharide (LPS) (0.5 mg/kg, i.p.) and 23 h following LPS separately in mice.
Results: The result of the present study indicated that mice treated with Loxoprofen showed a significant
decrease in the immobility time in forced swim test. LPS-treated mice presented an increase in immobility
time when compared to controls 24 h after LPS administration. Similarly Loxoprofen could only reverse but
did not prevent the LPS-induced alterations in the FST.
Conclusion: The results of the present study indicated the possible anti-depressant effect of Loxoprofen in
mice subjected to forced swim test model of depression, having possible implication in future treatment of
depression.
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| Keyword:
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Depression, Forced Swim Test, Lipopolysaccharide, Loxoprofen, Mice
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.380
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| Download:
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