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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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HPTLC Method for the Estimation of Atorvastatin, Losartan Potassium, Atenolol and Aspirin in Combined Dosage Form

Author: UPLOADED BY-ADMIN, A. MANIKANTA KUMAR, K. R. ALAGAWADI
Abstract: A simple, specific, accurate and precise high performance thin layer chromatography method was used to develop the estimation of Atorvastatin, Losartan potassium, Atenolol and Aspirin in tablet dosage form. For the High performance thin layer chromatography method, precoated silica gel 60 F254 was used as stationary phase and mobile phase consisted of methanol : chloroform : toluene : benzene : glacial acetic acid (7:2:0.5:0.5:0.05% v/v). The detection of spot was carried out at 220 nm and the Rf value was found to be 0.75±0.03, 0.41±0.01, 0.21±0.02, 0.63±0.05. The method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantification etc. in accordance with ICH guidelines. Linear regression analysis data for the calibration plot showed that there was a good linear relationship between response and concentration of the drug for high performance thin layer chromatography respectively. No chromatographic interference from tablet excipients was found. The proposed method was successfully used for estimation of Atorvastatin, Losartan Potassium, Atenolol and Aspirin in tablet dosage form.
Keyword: atorvastatin, losartan potassium, atenolol, aspirin.
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