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Protective Effects of 4-Allyl pyrocatechol Against Chemotherapy Induced Peripheral Neuropathy
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| Author:
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TIRUPATHI RAO ANNAVARAPU, SUJANA KAMEPALLI
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| Abstract:
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In this study, we have reported the protective effects of 4-allyl pyrocatechol (4-APC) from biochemical and functional deficits associated with oxaliplatin (OP) induced neuropathy. Oxaliplatin is the platinum-containing anticancer drug used for the treatment of colorectal cancer. It has the ability to develop peripheral neuropathy as a side effect. 4-allyl pyrocatechol acts as an antioxidant. The mice were administered with oxaliplatin three times weekly at 0.20 mg/kg with 4-APC (10 mg/kg & 30 mg/kg). The animals were submitted to mechanical and thermal hyperalgesia tests. Nerve conduction velocity measurement measurements were during the treatment period and at the end of treatment. Calpain system, Tumour cytotoxicity assay also assessed. 4-APC significantly prevented the mice from behavioral and biochemical alterations associated with oxaliplatin-induced neuropathy. In addition, we reported the inhibitory effect of 4-APC on the calpain system, which is associated with oxidative stress and neuroinflammation. Thus, we conclude from this study, the use of 4-APC with OP might reduce the number of patients who develop painful peripheral neuropathy.
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| Keyword:
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Calpain, Oxaliplatin, Peripheral neuropathy, Nerve conduction velocity, Hyperalgesia
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.714
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| Download:
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