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In Situ Nanogel Based Topical Spray for Treatment of Psoriasis
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| Author:
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SNEHA PATEL, DRASHTI PATHAK, DEEPA H. PATEL
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| Abstract:
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The target of current research was to develop and estimate in situ nanogel based topical spray for the
treatment of psoriasis. Polyvinyl alcohol (PVA) and hyaluronic acid (HA) with immunosuppressant drug in situ
nanogel can be applied on inflamed skin by topical delivery. Differential scanning calorimetry was used to study
the incompatibility of drug-excipients. UV spectrophotometer was used to develop analytical method. The
nanogel was successfully prepared using by chemical crosslinking method and evaluated for viscosity, pH,
particle size, zeta potential, Entrapment efficiency, gelling time, surface morphology (Transmission Electron
Microscopy), in vitro drug release, stability study for nanogel formulation and drying time, volume per spray,
area of film, dose uniformity for topical spray formulation. For optimization, 32 full factorial designs for
Dimethylfumarate containing in situ nanogel have been used to study the effect of independent variables on
dependent variables. Particle size and zeta potential were found to be 290 ± 1.2 nm and -1.81 ± 3.20 mV
correspondingly for optimized batch. Entrapment efficiency were found to be 85.80% ± 0.34. Transmission
Electron Microscopy (TEM) study specifies that the particles were found to be in sphere shaped shape and
porous in nature. Drug release were found to be and 86.60 ± 0.31 % in 06 hrs at in vitro condition. Gelling
time was found to be 7±0.1 mins. The stability study shows that the lyophilized Nanogel remained stable at 40
± 2°C/75±5% at accelerated condition after 3 months. The present study confirmed that in situ nanogel based
topical spray has good effect on psoriasis skin pH than other dosage form. The topical spray cover enlarge portion of the skin without irritation and exerts effect on the skin.
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| Keyword:
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Nanogel,psoriasis, Dimethyl fumarate, hyaluronic acid, polyvinyl alcohol, glutaraldehyde
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.365
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| Download:
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