|
Formulation and Evaluation of Disopyaramide Phosphate Loaded Microbeads
|
|
| Author:
|
MANDAKINI HOLKAR, SNEHAL CHAKORKAR, JAGADEVAPPA S PATIL
|
| Abstract:
|
Background: Disopyramide Phosphate, an anti-arrhythmic drug, and has oral bioavailability of 80% with a 6-8
hour biological half-life. Presently, on the lookout, various extended-release formulations of Disopyramide
phosphate are available. Objectives: In the current research, we specifically recommended the use of natural
polymer to design the extended-release formulation, which improves the biocompatible property of the
dosage form as compared with the conventional release dosage form. chitosan is picked as a copolymer to
obtain promising sustained release action alongside mucoadhesive action. Methods: Sustained release beads of
Disopyramide phosphate were prepared by ionotropic gelation technique involve; within the sight of
counterions, polyelectrolytes can cross-link and structure a coat on the drug core to form hydro gels with
sustain release action. In current work, microbeads are formulated utilizing various extents of sodium alginate
with or without chitosan and evaluated for, FTIR, DSC, Visual Appearance, SEM, Particle size, Percentage Yield
of microbeads, Drug Entrapment Efficiency, Swelling Index, In-Vitro Dissolution Studies, Release kinetic study
and Stability study. Result: The formulated Disopyramide phosphate loaded microbeads show maximum drug
Entrapment Efficiency, Swelling Index, In-Vitro Dissolution Studies, Release kinetic study, and Stability study.
The formulation S2 was oppressed for data modeling of zero-order, Higuchi, and Korsmeyer Peppas equation,
studies showed that all formulations followed zero order r2 value 0.984, Higuchi r2 0.916, and Peppas n value
0.892. The release data from all the formulation was found to fit zero-order models. The S2 formulation
demonstrated high drug entrapment efficiency and a possible sustained release profile from microbeads.Mandakini Holkar et al / Formulation and Evaluation of Disopyaramide Phosphate Loaded Microbeads
2765| International Journal of Pharmaceutical Research | Apr - Jun 2021 | Vol 13 | Issue 2
Conclusion: From the experimental findings it tends to be gathered that the formulated Disopyramide phosphate microbeads show the stable sustain release action.
|
| Keyword:
|
Antiarrhythmic agent; Ionotropic gelation; chitosan; Microbeads Disopyramide phosphate
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.02.161
|
| Download:
|
Request For Article
|
|
|