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In Silico Study to Establish Molecular Interaction between Plant Gene Clusters to Improve Metabolite Production
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| Author:
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HIMANSHU SINGH, VINEETH CHANGARANGATH, VIKAS KAUSHIK
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| Abstract:
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Organized microbial gene expression under the concept of operons is a well-established concept. An
operon-esque gene arrangement in the plant kingdom has been brought to the limelight with the help of recent
developments in genetics, biochemistry and bioinformatics. We aim to explore the interactions between various
gene products (enzymes) from the gene clusters of the 12 chromosomes in Oryza sativa Japonica and Oryza
sativa Indica. Sequence information of the all the reviewed signature and tailoring genes were retrieved. The
3-dimentional structures of these proteins were predicted using Bioinformatics tools. The interactions among
various predicted structures were ascertained by molecular docking techniques. The hypothesis that the
various signature gene products and the corresponding tailoring gene products of the gene clusters of Oryza
undergo protein-protein interaction was substantiated by the reliable molecular docking results reveals perfect
interaction which leads to production of metabolites. The dendrogram generated for each signature gene
products displays the evolutionary relationship with similar proteins from other species or the
predicted/hypothetical proteins suggested by the algorithm
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| Keyword:
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Oryza sativa, Enzyme, Molecular Docking, and Evolutionary relationship
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.324
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| Download:
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