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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Time to Success and Its Prognostic Factors among Patients with Myringoplasty Surgery

Author: EMY ASMAR BADRUDDIN, YU CHYE WAH, KOH KIM HUA, KSHTRASHAL SINGH, SUSMITHA GOVIND
Abstract: Myringoplasty is a surgical ear procedure indicatedto treat perforation of tympanic membraneandto prevent further ear infection and improving hearing. Success rate has been a concern for patients with different indications. This study aims to determine the time to success in myringoplasty surgery and to identifyprognostic factors contributing to its success. A retrospective cohort study was conducted on 215 patients diagnosedas tympanic membrane perforations and with myringoplasty surgery done from 2008 to 2017. Results from Kaplan Meier analysis showed overall median time to success in myringoplasty was 19.9 (95%CI: 13.6, 44.0) months. Multiple Cox Proportional Hazard Regression revealed that age, gender, smoking status, upper respiratory tract infection (URTI), size of perforation, affected side, graft used, and rank of surgeon were significantly associated with success rate of myringoplasty. Success of a myringoplasty appeared to be lower than commonly quoted success rates due to difference of patient’s selection criteria, the definition of success as well as the duration of follow up after surgery. Time to success, postoperative expected outcome and the prognostic factors should be properly counselledto patients whentakingintoaccountofvariousdefinitionsofsuccessasunrealisticsuccess expectation is contraindicated for myringoplasty.
Keyword: myringoplasty, surgical success rate, graft uptake, prognosis, hearing improvement
DOI: https://doi.org/10.31838/ijpr/2021.13.01.706
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