|
|
|
|
|
|
Article Detail
|
|
Label
|
|
|
Label
|
|
|
|
Effect of Spondias Mombin Ethanolic Extracts on Serum Lipid Profile and Serum Glucose Levels on Streptozotocin – Induced Diabetes Male Albino Rats
|
|
| Author:
|
, STANLEY CHUKWUMA OKEREKE, OKEZIE VICTOR IKPEAZU, CALEB JOEL NWAOGWUGWU, FRIDAY OBINWA UHEGBU, EMMANUEL AKARA, IJEOMA CHIDI NOSIRI, AHAMEFULA SUNDAY EZEKWE, CHRISTOPHER UGOCHUKWU AGHALIBE, AGUWAMBA CHINEDU
|
| Abstract:
|
This study was carried out to investigate the effects of Spondias mombin (leaf, root, seed and stem bark)
ethanolic extract on serum lipid profile and serum glucose levels of strepzotocin - induced diabetic male albino
rats.Thirty-five assumed healthy albino rats (8 weeks old) weighing between 66g and 84g were collected from
the Animal house of Department of Biochemistry, Abia State University, Uturu, Nigeria. The animals were
randomly placed into 7 groups. Group 1: Served as normal control, 2 served as diabetic control group were
not treated, 3 served as diabetic group treated with a standard drug glycinorm at 80mg/kg body weight, 4
served as diabetic group and were treated with ethanolic extracts of Spondias mombin leaf at 500mg/kg body
weight, 5 diabetic group treated with ethanolic extracts of Spondias mombin stem bark at 500mg/kg body
weight, 6 diabetic group treated with ethanolic extracts of Spondias mombin root at 500mg/kg body weight
and 7 diabetic group treated with ethanolic extracts of Spondias mombin seed at 500mg/kg body weight by oral
administration respectively. Diabetes was induced in albino rats by intraperitoneal injection of strepzotocin at a
single dose of 120 mg/kg body weight into group 3 to 7 and were subsequently treated with ethanolic extracts
of the different parts of Spondias mombin for a period of 28 days. Glucose levels were measured on days 0 7,
14, 21, and day 28. Animal were sacrificed on the 29th day and serum lipid profile and serum glucose levels
measured using standard laboratory methods. The administration of streptozotocin significantly increased
(p<0.05) the levels of cholesterol, HDL, Triacylglycerol, LDL and VLDL respectively when compared to the
normal control (p<0.05). Standard drug (glycinorm, 80mg/kg) and Spondias mombin extracts decreased the
concentration of these macromolecules. There was a general decreasing trend in the mean values of lowdensity lipoprotein levels across the groups, however cholesterol, HDL LDL and Tricylglycerol shows
significant decrease across all t1997he groups when compare with group 2. The ethanolic extract of Spondias
mombin (leaf, seed, stem bark and root) decreased (p<0.05) significantly serum glucose levels in the diabetic rats.
Spondias mombin extracts may be a potent antidiabetic agent. This provides claims that the plant (stem bark,
leaves, root and seeds) was able to ameliorate abnormalities associated with Diabetes Mellitus, hence used in
the management of diabetes in alternative medicine practice. It also shows the plant possess antilipidemic and
hypoglycemic properties. This study suggests that ethanolic extracts of Spondias mombin plant parts have active
components that are capable of lowering serum glucose level and serum lipid profile and this might be useful in the management of diabetes mellitus and cardiovascular diseases
|
| Keyword:
|
Spondias mombin, Antilipidemia, Hypoglycemia, Streptozotocin, Antidiabetes
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.02.296
|
| Download:
|
Request For Article
|
|
|
|
|
|
|
|
|
|
|