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Left ventricular diastolic dysfunction in Type 1 Diabetes Mellitus: The potential nexus
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| Author:
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, DR.BASIM SAFI NAJI ALMGOTER, HAYDER M.AL-KURAISHY
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| Abstract:
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Objectives: To assess the impact of long-lasting type 1 diabetes mellitus (TIDM) on the myocardial function.
Methods: The case-control study was conducted at the Department of Pharmacology, College of Medicine,
Mustansiriya University, Baghdad, Iraq, from July to October 2018 and involved forty T1DM patients compared
with forty healthy control subjects. Anthropometric and pressure profiles were evaluated. As well,
echocardiographic findings were estimated in both groups. SPSS version 20.00 was used for data analysis.
Results: No significant differences were noted in the parameter of the two groups (p>0.05). The duration of
their illness was (5-20) years (mean 11±3) years. The peak early basal annular velocity (E` wave) was reduced
in TIDM patients compared to the controls (P=0.00001). As well, other echogradiographic variables were
impaired in TIDM patients compared to the controls (P=0.00001) with exception of A (cm/s). Besides, LVEDD,
LVESD and EF were not significantly differed in TIDM patients compared to the controls (P>0.05). Moreover,
the effect of duration of T1DM on the left ventricular diastolic function by dividing those forty patient into two
subgroups, those with the disease duration of more than (10 years) which include (23) patient (57.5%) and
those with the disease duration of less than (10 years) and include (17) patient (42.5%), and comparing their
finding with that of the control group. However, in TIDM patients with duration <10 years only E (cm/s) was
differed which was lower in TIDM patients compared with the controls. Conclusion: T1DM inducedmyocardial dysfunction is duration dependent and linked with underlying diabetic complications.
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| Keyword:
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diabetic complications, type 1 diabetes mellitus, echogradiographic variables
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.302
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| Download:
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