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Ultra-deformable vesicular carriers for enhanced Permeation of Drugs.
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| Author:
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E HIMA BINDU, DR.G.V.RADHA
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| Abstract:
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In recent years the use of intact skin has been explored as a dormant route of drug administration. The drug
can be delivered into the systemic circulation in a very continuous and a controlled manner through this route.
Because of this reason, more focus has been kept by the researchers on Transdermal drug delivery. But the
drug delivery through this route is restricted by the barrier function performed by the skin. This limitation can
be successfully overcome by the use of Transferosomes as drug carriers. Transferosomes are the flexible,
deformable vesicular carriers that can penetrate the skin through the very tiny pores that are present in the
cells of the skin. Due to their deformable nature, they can squeeze themselves through these pores which are
very smaller than the vesicular carriers. Transferosomes can be formulated by employing phospholipids and
edge activators in different ratios. Because of their amphiphilic nature, theycan accommodate hydrophilic,
lipophilic, and amphiphilic drugs. These different types of drugs search for a suitable place in the elastic vesicles
before they get delivered underneath the skin. Transferosomes are also deployed in the administration of
controlled-release formulations, Anti- Cancer drugs, Proteins, Peptides, and drugs with high molecular weight
like insulin. Targeting the drug peripherally and immunization through the transdermal route can also be
achieved by this novel type of delivery system
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| Keyword:
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Transferosomes, Deformable Vesicular Carriers, Transdermal Drug Delivery, amphiphilic.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.298
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| Download:
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Request For Article
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