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Citrus flavonoids - nature’s boon in cancer therapeutics
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| Author:
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KIRANMAI GUDIMETLA, DR.ABHISEK PAL
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| Abstract:
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Flavonoids are richly found in fruits and vegetables, utilized as chemopreventive agents. The molecular study of
flavonoids shows that they arrest the cell cycle, inhibits heat-shock protein, inhibits tyrosine kinase, decreased
p53 protein expression, estrogen receptor-binding capacity, Ras protein inhibition. Proliferation of cancer cells
has been inhibited by citrus flavonoids such as diosmin, rutin, apigenin, tangeretinin in different classes of human
cancer cell line cultures. Flavonoids play a crucial role amongst the known inhibitors of angiogenesis. The major
functions of citrus flavonoids are they act as reducing agents, metal chelators, scavengers of reactive oxygen
species, antioxidants, singlet oxygen formation quenchers, and protectors of ascorbic acid. Flavonoids having
that capability to inhibit DNA damaging, mutagenic signalling, cell proliferation and also proto-oncogenes (cFOS,
cJUN, and cMyc). A systematic mechanism is to be developed to understand the flavonoids' mechanism when
entering multiple cell organelles and tissues. Flavonoids are probable to inflect various biological actions in cancer,
including apoptosis, vascularization, cell differentiation, and cell proliferation. The evaluation of pharmacokinetic
parameters and the distribution of citrus flavonoids across biological fluids is essential. Future research on citrus
flavonoids should focus on evolving a bio-system or method for exactly evaluating bio-accessibility and
bioavailability in-vivo. To prevent or treat human cancers, long-term clinical trials should be performed to study
the metabolism and cytotoxicity. To prevent or treat human cancers, long-term clinical trials should be
performed to study the metabolism and cytotoxicity. Further studies should be conducted to validate the
traditional ways of treating cancer
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| Keyword:
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Citrus flavonoids, cancer, anti-angiogenesis, anti-oxidant, anti-proliferation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.222
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| Download:
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Request For Article
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