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Molecular Docking and In-Vitro Studies of Some New Oxadiazole Derivatives As Antidiabetic Agent
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| Author:
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, DR JADHAV SHAILAJA BHANUDAS, SALVE MEGHA TUKARAM
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| Abstract:
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In this research, we explain first of all drug receptor interaction by molecular modeling. In the present analysis, 14 oxadizole derivatives containing 2-cyano pyrrolidine sulfonamide substituents were synthesized and structural elucidation study compound characterization was tested for their in vitro dpp-4 inhibitor as an antidiabetic properties compound A-III was found to be a potent DPP-4 inhibitor at conc 10 um concentration To standard vildagliptin. Both compounds have been subjected to molecular docking studies for inhibition of the DPP-4 enzyme. In molecular docking studies, all synthesis compounds with reduced binding energy and strong affinity to the active pocket have been shown to be as good Dpp-4 inhibitors as antidiabetic properties
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| Keyword:
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Type 2 diabetes (T2D), sulfonamide derivatives of 2-cyanopyrrolidine,molecular docking.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.138
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| Download:
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