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Synthesis and Evaluation of ALG-g-PNIPAm Copolymer With Dual Responsive Activity
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| Author:
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ARCHANA S. PATIL, RIYA HEGDE, PARIXIT BHANDURGE, RAJASHREE MASAREDDY, PANCHAXARI.M.DANDAGI
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| Abstract:
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The present study aimed to synthesize the pH and temperature responsive alginate-g-poly (Nisopropylacrylamide) (ALG-g-PNIPAm) co-polymer by two methods namely dispersion co-polymerization
method and free radical polymerization method and evaluate its dual responsiveness to be used as a carrier for
anticancer drug delivery. For this, the co-polymer was synthesized by both the methods with varying the
sodium alginate concentration and its base structure as well as lower critical solution temperature (LCST) was
determined. It was found that, the percent monomer conversion is higher with free radical polymerization and
the increase in LCST with respect to alginate concentration was found in dispersion copolymerization method.
The Capecitabine loaded co-polymeric nanoparticles were prepared by using ultrasonic probe sonicator and
the nanoparticles were evaluated for their physicochemical properties i.e particle size, PDI, loading efficiency
and in vitro drug release. The morphological study showed that Capecitabine loaded nanoparticles were
spherical and uniform in size. The loading efficiency was found to be in the range of 90.0%-97.6% respectively.
The in vitro stimuli triggered drug release study showed the higher percent drug release at acidic pH (6.8) and
higher temperature (35±0.5 0C) as compared to alkaline pH 7.4 and temperature 37±0.5 0C. In conclusion, the
developed co-polymeric nano particulate system is an effective dual responsive carrier which can be efficiently
used for Capecitabine delivery after proper optimization to achieve targeted drug delivery.
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| Keyword:
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Capecitabine, Alginate, Poly (N-isopropylacrylamide), pH and temperature responsive co-polymer
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.281
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| Download:
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