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Comparative Pharmacological Evaluation of Various Extracts of Cajanus Cajan (Leaves), Caesalpinia Pulcherrima (Leaves) and Tamarindus Indica (Flowers) on Anxiolytic Activity in Mice
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| Author:
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BALAKRISHNA VUYYALA, DR D SENTHIL KUMAR, DR THAKKALAPALLY LAKSHMI
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| Abstract:
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Anxiety is a natural human state wherein everybody experiences in their life. Anxiety is the foremost common
psychological state problem within the world and it increases rapidly. The Objective of the present study was a
comparative investigation of the antianxiety activity of three traditionally used medicinal plants- Cajanus cajan
(Leaves), Caesalpinia pulcherrima (Leaves), and Tamarindus indica (Flowers). The activity of various extracts nhexane, chloroform, ethyl acetate, and methanol of all 3 plants was evaluated using an elevated plus maze and
Actophotometer models. The studies were conducted on Swiss albino mice and the test materials were
administered per oral route. In contrast of selected 3 plants, results indicate that the methanol extract of
Tamarindus indica flowers showed maximum and significant dose-dependent effect at 200 and 400 mg/kg on
Elevated plus maze and Actophotometer models, the results were just like the standard antianxiety agent
diazepam (2 mg/kg). The results were shown to be decreased in a dose-dependent model compared to
control. As the phytochemical screening of methanol extract exhibited the presence of polyphenols could be
liable for the anxiolytic potential of T.indica. Hence this plant could also be used as a useful anti-anxiety agent.
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| Keyword:
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Perennial legume, Dwarf poinciana, Cinca, Activity cage, Behavioural method, Tranquilizer.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.267
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| Download:
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