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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development Of Immediate Release Capsule And Immediate Release Tablet Formulated Using Spray Dried Amorphous Solid Dispersion Of Febuxostat

Author: VAISHALI PATEL, ANITA PATEL, ASHISH SHAH
Abstract: Introduction: Febuxostat belongs to BCS class II drugs, which having low solubility and high permeability. Amorphous solid dispersion is one of the techniques which can be used to improve solubility and powder characteristics. Objective: To enhance dissolution rate and solubility of febuxostat by making amorphous solid dispersion of the drug. To produce Immediate Release tablets and capsules by using batch that gives highest solubility (FSD 6). Method: The amorphous solid dispersion of febuxostat was prepared by spray drying method using Kolliphor P237(1:2). This amorphous solid dispersion was further used to compress immediate release tablet and capsules. The prepared tablets were characterized by pre compression and post compression parameters. Dissolution Efficiency (%DE) and Mean Dissolution Time(MDT) was calculated for both the dosage forms. Accelerated stability studies was performed for FSD 6 tablets and FSD 6 capsules. Results: The solubility was enhanced by 45.44 times after formulating amorphous solid dispersion of febuxostat as compared to pure drug. Mean dissolution time for FSD 6 capsule dosage form was found to be better than FSD 6 tablets. Conclusion: The combination of hydrophilic and hydrophobic polymer showed increased solubility and hence dissolution rate of the drug. FSD 6 capsules dissolve faster than the Immediate Release FSD 6 tablets.
Keyword: Febuxostat, spray drying method, solubility, Immediate Release dosage forms.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.237
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