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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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To Evaluate the Effect of Estrogen Receptor Alpha (ER- a) Variant in Conjunction With Vitamin D Among PostMenopausal Women

Author: FARUQUE AHMED, PALLAVI ANAND, PAWAN A.KULKARNI, ANIL KUMAR
Abstract: Background: Vitamin D, also known as the ‘sunshine-hormone’ that offers numerous benefits for women who are experiencing menopause. For women going through the menopause, the lack of natural Vit-D can bring many issues like increased risk of developing CVD, reduced cognitive function and osteoporosis. Material and Methods: The present study was conducted in the Department of Biochemistry with the collaboration of Department of OBG & GYNE. Participants in the study donated 10 ml of blood which was collected aseptically in serum separation. Samples were processed as soon as possible, latest within 2 hours of collection; in order to prevent DNase, RNase and protease activity. Serum separation tubes were spun at 5900 x g for ten minutes and supernatant serum was subsequently divided with the help of transfer pipette into aliquots of at least 200 µl in each cryo-vial marked a, b, c and sample ID as prefix. Result: Frequency distribution of Estrogen receptor –a polymorphism of PvuII in Premenopausal were CT 43.24% genotype and followed by CC 36.04% and least genotype was TT 20.72%. Furthermore, Postmenopausal Women PvuII was more CT 45.22% genotype and followed by CC 34.78% and least was TT 20% in table. Frequency distribution of Estrogen receptor –a polymorphism of Xbal in Premenopausal were AG 54.95% genotype and followed by AA 25.23% and least genotype was GG 19.82%. Furthermore, Postmenopausal Women Xbal was more AG 55.65% genotype and followed by AA 25.22% and least was GG 19.13%. Conclusion: Early diagnosis of vitamin D deficiency and definitive management can prevent many complications that could affect child health and cause burden on the community. We recommend promoting healthy diet and physical activities for postmenopausal women to prevent obesity and vitamin D deficiency
Keyword: Vitamin D deficiency, Menopause, Osteoporosis
DOI: https://doi.org/10.31838/ijpr/2021.13.02.234
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