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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antipsychotic Evaluation of Novel Series of Aryl Piperazine Congeners

Author: DARAKHSHAN GAZALA BARI, K SARAVANAN, RIZWAN AHMAD
Abstract: This proposal would synthesize the work on arylpiperazine derivatives because aryl piperazine has the largest amount of positive effects on the biological screen of the heterocyclic and its congeners as the most important building blocks for drug development. Two separate series of N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4- (arylsubstituted) piperazines-1-yl]acetamide and 2-[4-(arylsubstitution)piperazine-1-yl]acetamide are synthesized and are distinguished by various substituents of aryl piperzine, such as a melting point determination and chromatography in thin-scale (TLC). Two different series are also performed, synthesized and characterized. Its spectroscopic characterisation was undertaken for their structure elucidation. Followed by this, synthesized drugs can be pharmacologically assessed. In pharmacological research, the inhibition of 5- hydoxytraphtophen (5-HTP) mediated head twitches, the inhibition of the behaviour, and the activation of cataleptic disorder are determined by the behaviours.
Keyword: Aryl piperazine, characterization, melting point, thin layer chromatography (TLC), pharmacological evaluation, apomorphine, 5-hydoxytryptophan (5-HTP), catalepsy
DOI: https://doi.org/10.31838/ijpr/2021.13.02.235
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