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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antibacterial and Antiparasitic Biosurfactants Produced by Candida Cruzi in Different Nitrogen and Carbon Sources

Author: AHMED ABD BURGHAL, WIJDAN HUSSEIN AL TIMIMI, ATHRAA ABD-ULAMEER AL-HILFI
Abstract: One of the most remarkable products that have important in the medical application is biosurfactants. In the present study biosurfactants produce by Candida cruzi partially purified. The result of Infra-Red Spectroscopy showed the presence of different chemical groups. The antibacterial activity of optimized biosurfactants was performed with different types of Gram-positive and negative clinical isolates. The biosurfactants produce from media supplied with glucose has the more potent inhibitory activity against all isolates, the maximum inhibition zone diameter was 22mm on E. coli while nitrogen source the largest inhibition zone is 20mm when the produce of biosurfactants with asparagine and peptone of all isolates. The result of antiparasite against Naegleria fowleri, by biosurfactants suspension, showed a high decrease in numbers of parasites after 72h at 250µl (50% activity) of biosurfactants extracted from lactose media and (40% activity) from asparagine media at 500µl after 72h. The antioxidant show the biosurfactants from different source have an activity to inhibition of DPPH free radicals, the percentage of activity was 46.5% at 10mg/ml compared with ascorbic acid. The significant inhibitory effect of biosurfactants against microbes indicates the possibility of using it in the medical and pharmaceutical.
Keyword: Biosurfactants, Antibacterial, Antiparasitic, Antioxidant, Candida cruzi.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.204
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