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Antibacterial and Antiparasitic Biosurfactants Produced by Candida Cruzi in Different Nitrogen and Carbon Sources
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| Author:
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AHMED ABD BURGHAL, WIJDAN HUSSEIN AL TIMIMI, ATHRAA ABD-ULAMEER AL-HILFI
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| Abstract:
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One of the most remarkable products that have important in the medical application is biosurfactants. In the
present study biosurfactants produce by Candida cruzi partially purified. The result of Infra-Red Spectroscopy
showed the presence of different chemical groups. The antibacterial activity of optimized biosurfactants was
performed with different types of Gram-positive and negative clinical isolates. The biosurfactants produce from
media supplied with glucose has the more potent inhibitory activity against all isolates, the maximum inhibition
zone diameter was 22mm on E. coli while nitrogen source the largest inhibition zone is 20mm when the
produce of biosurfactants with asparagine and peptone of all isolates. The result of antiparasite against
Naegleria fowleri, by biosurfactants suspension, showed a high decrease in numbers of parasites after 72h at
250µl (50% activity) of biosurfactants extracted from lactose media and (40% activity) from asparagine media at
500µl after 72h. The antioxidant show the biosurfactants from different source have an activity to inhibition of
DPPH free radicals, the percentage of activity was 46.5% at 10mg/ml compared with ascorbic acid. The
significant inhibitory effect of biosurfactants against microbes indicates the possibility of using it in the medical
and pharmaceutical.
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| Keyword:
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Biosurfactants, Antibacterial, Antiparasitic, Antioxidant, Candida cruzi.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.204
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| Download:
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