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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Kinetic Parameters on L-Asparaginase from Streptomyces Albogriseolus

Author: MITHILESH KUMAR, VENKATESH KAMATH B, MRINALINI R, ARAVINDA PAI, BHAVANA B BHAT, ASWATHA RAM H N
Abstract: L-Asparaginase is an essential entity in treating acute lymphoblastic leukemia and other types of Blood Cancers. The inhibitory action of the L-Asparaginase on the synthesis of Proteins associated with tumor cells, makes it a very sought after first-line treatment choice for acute lymphoblastic leukemia and associated diseases. L-Asparaginase is processed by a varied range of source including animals, plants and microorganisms, where this article focuses on the microorganisms producing a substantial quantify of the enzyme. The novel microorganism of interest is Streptomyces albogriseolus, which is an aerobic, Gram-positive bacteria. This bacterial strain is found to secrete a broad spectrum of chemicals such as L-Asparaginase, eunicellin diterpenoids and various alkaloids to name a few. The L-Asparaginase isolated from Streptomyces albogriseolus is subjected to different test conditions to detect the ideal conditions for the maximum enzymatic activity. The parameters considered for the ideal conditions were substrate (L-Asparagine) concentration, pH and temperature. The test results showed that 0.04M substrate concentration, pH 8.0, and 40ºC temperature were the optimal test conditions under each parameter taken.
Keyword: Streptomyces albogriseolus, substrate concentration, pH, temperature, L-Asparaginase.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.210
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