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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Determination of Naproxen and Esomeprazole Using HPTLC

Author: VIVEK INGALE, TRUPTI JAMBHALE, VIPUL DHASADE, AMIT KASABE, SANTOSH FATTEPUR, NAGARAJA SREEHARSHA
Abstract: To simultaneously determine naproxen and esomeprazole as a bulk drug and laboratory combination, a simple, delicate, accurate and high performance thin-layer (HPTLC) method was developed and validated. Separation was carried out as a stationary process on aluminium-backed silica gel 60F254 HPTLC. The solvent system was formed by mobile phase ethyl-acetate - methanol - ammonia (8.0: 1.26: 0.54 v/v). Camag TLC scanner 3 was used in the absorbance mode at 272 nm to conduct the densitometric scanning. The method mentioned has the benefit that it is fast and clear.
Keyword: Naproxen, Esomeprazole, HPTLC, Validation
DOI: https://doi.org/10.31838/ijpr/2021.13.02.227
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