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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Review on Bioanalytical Method Development and Validation for the Estimation of Metformin in Biological Matrices

Author: BHUVANESHWARAN ANANDAMOORTHY, NAGARAJAN JANAKI SANKARACHARI KRISHANAN, ANBU KANNAN, APARNA SEBASTIAN, BALASUNDARAM MURALITHARAN
Abstract: Metformin is an oral anti-hyperglycaemic drug used for treating type ? diabetes mellitus. Metformin is available in the form of a solid dosage form in the market. A various number of instrumental methods like Reverse Phase-High performance liquid chromatography, Liquid chromatography coupled to mass spectrometry, and ultra-performance liquid chromatography are available to quantify the metformin either in formulations or biological fluids namely blood or serum, or urine. To analyse metformin in a biological fluid is challenging one it is because of enrichment of analyte from the biological fluids as well as the selection of the proper method to estimate. Apart from the enrichment of analyte from the biological fluids, due to its polarity is also one challenge to estimate the drug. Many others have developed and validated. We have collected the article and reviewed the analysis of metformin in biological fluids.
Keyword: Bioanalytical methods; metformin; RP-HPLC; LC-MS; UPLC
DOI: https://doi.org/10.31838/ijpr/2021.13.02.220
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