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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study of Bacterial Isolates and their Antibiotic Resistance Pattern in Post Burn Patients at Tertiary Care Centre

Author: DR SANA AFREEN, DR SUDANSHU TRIPATHI, DR FATIMA KHAN, DR M FAHUD KHURRAM, DR IMRAN AHMAD
Abstract: Introduction: Post burn wounds are more susceptible to infections due to damage to skin and leakage of serum containing essential growth factors. Thorough knowledge of microorganisms associated with burn wound helps in understanding the antibiotic susceptibility and also the pattern of multidrug resistance. Objective: As very few studies are available from India that have studied different microorganism isolated from burn wound and development of resistance, current study focused on bacteria associated with burn wound and their resistance pattern. Method: Patients with 20-70% total body surface area burns and who were followed up for their entire hospital stay were included in this study. Surface wound swab for culture and sensitivity were collected on 1,3,7,10,14 days after admission. Environmental sampling was done every 3 months. Results: Among 260 samples from 184 patients, 24 were sterile, 208 samples yielded 260 isolates. Pseudomonas species was predominantly isolated (24%) followed by E.coli (23%), Klebsiella (20%) and S.aureus (14%). Maximum antibiotics resistance was seen to ceftriaxone and sulbactum ( especially with Enterobacteriaceae infections). Pseudomonas species and gram-negative bacteria also demonstrated high antibiotics resistance. Conclusion: Good environmental contamination control and disinfection with proper hand washing and barrier precaution is recommended for prevention of post burn wound infection. Early isolation and identification of MRSA is prudent to minimize multidrug resistance in post burn patients.
Keyword: Post burn wounds, S.aureus (MRSA), Infection, Antibiotic resistance
DOI: https://doi.org/10.31838/ijpr/2021.13.02.199
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