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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RP-HPLC Method Development and Validation for the Estimation of Cefpodoxime Proxetil in Bulk and Pharmaceutical Dosage

Author: SHAIKH SIRAJ N, SANDEEP S KSHIRSAGAR, G J KHAN, PATEL M SIDDIK N, M Y KHALIFA, MAKRANI SHAHARUKH I, ANSARI YASIR A RAZZAQ, JAYESH C CHAUDHARY
Abstract: The objective of present work was to develop and validate a simple, accurate, precise RP-HPLC method for the estimation of Cefpodoxime Proxetil in Bulk and Pharmaceutical Dosage Tablet form. The separation was done by using Agilent technology RP-HPLC .Column Agilent C18 (4.6 x 150 mm, Particle size 2.5 ) with Mobile Phase was Methanol : 0.1 % Ortho phosphoric acid ( OPA) Water pH -4.2 with Triethylamie (20:80% v/v). The flow rate was 0.7 ml/min, and the analytes were measured at ?max 236 nm. The retention time for Cefpodoxime Proxetil was 4.864 min, respectively. The method was validated with respect to system suitability, linearity, precision, accuracy, and specificity, limit of detection (LOD), limit of quantification (LOQ), robustness and ruggedness. Linearity studies was performed (5–25µg/ml), The LOD of Cefpodoxime Proxetil was determine at 0.1579 and LOQ 0.4786 is respectively. These data show that method is sensitive for the determination of Cefpodoxime Proxetil.The relative standard deviation for accuracy was found to be less than 2%. The mean percentage recovery was 101.08 to 99.97% . The results of recovery studies indicate that the proposed method is highly accurate. The proposed validated method was successfully applied to determine Cefpodoxime Proxetil in tablet dosage form. The proposed method shall prove equally effective to analyze Cefpodoxime Proxetil in the corresponding drug sample and may prove to be of great importance in pharmaceutical analysis
Keyword: Cefpodoxime Proxetil, Methanol, Ortho phosphoric acid, Method Development, Linearity, Precision.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.160
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