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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Study to Assess the Impact of Vitamin C and E Intervention on Biochemical Profile of Newborn Baby with Birth Asphyxia

Author: KSHIRSAGAR VY, RITHIKA D, MOHITE RV
Abstract: Background: Worldwide neonatal mortality is mainly due to asphyxia at birth with significant higher contribution from developing countries. Objectives: To assess the biochemical changes in birth asphyxiated newborns before and after Vitamin C and Vitamin E administration. Methodology: Non-randomized pre and post intervention study was carried out with matched controls at neonatal ICU among birth asphyxiated term neonates delivered at rural tertiary health care centre. The study duration was completed within of six months in the year 2019. The study enrolled 50 cases and equal number of controls and interventions with Vitamin C and E was carried out in study group. All the clinical history, demographic information, examination findings and biochemical parameters values were noted into the case record proforma and analyzed for inferential statistics by using SPSS Version 20. Results: The total leukocyte count was significantly decreased in intervention group from 16593.32 to 13292.44 with apparent difference in controls. Mean platelet count was significantly increased from 1.4396 to 2.0236. The mean SGOT and SGPT levels were significantly decreased from 169.74 and 56.76 to 94.44 and 40.76 respectively. Serum levels of total proteins, albumins and levels were significantly hiked from 5.09 to 5.43, 2.98 to 3.59 and 2.23 and after 3.12 respectively. The serum LDH and creatinine levels were decreased from 1683.72 to 775.4 and 1.26 to 0.69 and difference was statically significant in study group respectively. Conclusion: The study concluded that after administration of Vitamin C and E, biochemical parameters showed protective changes in neonates with birth asphyxia
Keyword: Neonate, asphyxia, Vitamin C, Vitamin E, intervention, biochemical profile.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.219
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