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A Study to Assess the Impact of Vitamin C and E Intervention on Biochemical Profile of Newborn Baby with Birth Asphyxia
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| Author:
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KSHIRSAGAR VY, RITHIKA D, MOHITE RV
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| Abstract:
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Background: Worldwide neonatal mortality is mainly due to asphyxia at birth with significant higher
contribution from developing countries. Objectives: To assess the biochemical changes in birth asphyxiated
newborns before and after Vitamin C and Vitamin E administration. Methodology: Non-randomized pre and
post intervention study was carried out with matched controls at neonatal ICU among birth asphyxiated term
neonates delivered at rural tertiary health care centre. The study duration was completed within of six months
in the year 2019. The study enrolled 50 cases and equal number of controls and interventions with Vitamin C
and E was carried out in study group. All the clinical history, demographic information, examination findings
and biochemical parameters values were noted into the case record proforma and analyzed for inferential
statistics by using SPSS Version 20. Results: The total leukocyte count was significantly decreased in
intervention group from 16593.32 to 13292.44 with apparent difference in controls. Mean platelet count was
significantly increased from 1.4396 to 2.0236. The mean SGOT and SGPT levels were significantly decreased
from 169.74 and 56.76 to 94.44 and 40.76 respectively. Serum levels of total proteins, albumins and levels
were significantly hiked from 5.09 to 5.43, 2.98 to 3.59 and 2.23 and after 3.12 respectively. The serum LDH
and creatinine levels were decreased from 1683.72 to 775.4 and 1.26 to 0.69 and difference was statically
significant in study group respectively. Conclusion: The study concluded that after administration of Vitamin
C and E, biochemical parameters showed protective changes in neonates with birth asphyxia
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| Keyword:
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Neonate, asphyxia, Vitamin C, Vitamin E, intervention, biochemical profile.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.219
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| Download:
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