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Antineoplastic Marine Secondary Metabolites: Drugs, Drug-Candidates Under Clinical Trials, and Scaffolds of Potential Anticancer Activity
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| Author:
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ABDEL-NASSER EL-SHORBAGI, SACHIN CHAUDHARY, ALAA ALI ALJARAD, ESRAA OMER, FATMA MAHMOUD, RAMESH KUMAR GUPTA, AMIT KUMAR, MAHMOUD H. MOHAMED
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| Abstract:
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Marine environment is among the substantial sources of biologically active agents that own diverse
pharmacological properties such as radical scavenging, anti-cancer, antimicrobial, antiviral and analgesic
activities. Marine metabolites are considered as an alternative source to meet the demand for effective safe
and low-cost drugs. Cancer is one of the leading causes of death in the world. Despite notable developments
in cancer treatment in the past decades, there remains an urgent need for innovative drugs in the field of
cancer biology, particularly from the less explored area of marine-potential-anticancer compounds.
Nevertheless, new technological innovations in the detection of the structure, the semi-synthetic and synthetic
preparation of the new compounds. Biological assays facilitate isolation and clinical evaluation of numerous
unique anti-cancer compounds from the marine environment. This review gives a general summary about
marine natural products (MNPs) as anti-cancer agents and describes their mechanisms of action in addition to
drug-candidates under clinical trial phases (I-III) with their current status has also been enlisted.
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| Keyword:
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Marine drugs, Cancer, Antiviral, Analgesic, Clinical trial.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.205
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| Download:
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Request For Article
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