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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Hemidesmus Indicus Extract on Neuro Disorder Related Parameters

Author: B SIVARAMAKRISHNA, S MURALI MOHAN
Abstract: Cholinergic neurons are positive markers for the evolution of memory and other associated disorders affecting the activity of acetylcholine esterase, dopamine, serotonin, epinephrine and norepinephrine. In this report Hemidesmus indicus extract was found to inversionize the levels of various neurotransmitters when administered against copper chloride and calcium fluoride and could thus be responsible for improving learning, memory, cognition and motor functions. This study also reports brain alterations in histopathological studies that cause cognition loss and oxidation damage to the induced biochemical changes, including inhibition of the activities of antioxidant enzymes, activation of Cucl2 microglia and exposure to CaF2. Hemidesmus indus extract reversed the histological changes induced and mitigated the activation of the microglia. This gives proof of the effective brain delivery of hemidesmus indus and establishes for the first time the curativetherapeutic role of hemidesmus indicus, such as symptoms and cognitive losses induced in AD.
Keyword: Hemidesmus indicus, Dopamine, serotonin, Histopathological studies, Neurotransmitters.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.144
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