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Optimization of Acyclovir Self-Microemulsifying Drug Delivery Systems (SMEDDS) by Full Factorial Design
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| Author:
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DHARMENDRA SINGH RAJPUT, DR.SHAILESH JAIN
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| Abstract:
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The present analysis plans to methodically optimize and develop a Self micro emulsifying drug delivery system
to advance the solubility and oral bioavailability profile of Acyclovir. The incorporated formulation method is
the selection of the oil phase based on studies of saturated solubility and of surfactants and co-surfactants
based on their emulsification ability. To recognize the capable self-emulsifying zone, pseudo-ternary phase
diagrams were prepared. For knowing the interaction behavior of desired responses, the Box-Behnken
framework was used and configured using the appropriate method. Based on process optimization best
formulation of SMEDDS was selected and it consists of acyclovir 50 mg , 40 % sunflower oil, 40 % tween 60,
and 20% glycerol.
At the last, the selected optimized formulation was tested for droplet size analysis, phase separation study, self
emulsification time, transmittance, turbidity analysis, and zeta potential. Based on results it is concluded that
SMEDDS can be a better choice to optimize the oral delivery of acyclovir.
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| Keyword:
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Acyclovir, Oral drug delivery, Self-Microemulsifying Drug Delivery Systems, Bioavailability, Solubility enhancement, Optimization
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.191
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| Download:
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