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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Evaluation of Some New Quinoline Based 1, 3, 4-Oxadiazoles as Potential Antimicrobial and Antimalarial Agents

Author: HEMALATHA GADEGONI, SARANGAPANI MANDA, SHIVAPRASAD RANGU, SYEDA NISHAT FATHIMA
Abstract: A series of novel 2-(5-penyl-[1,3,4]oxadiazol-2-yl)-quinolines (5a-g) from benzoic acid N'-(quinoline-2- carbonyl)-hydrazides (4a-g) were synthesized in good yields by involving quinoline-2-carboxylic acid (1) as raw material and quinoline-2-carbonyl chloride (2) and quinoline-2-carboxylic acid hydrazide (3) as reactive intermediates. The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR and Mass spectral data. Further, all the compounds were screened for their antifungal and antiplasmodial activity.
Keyword: Qinolino-1,3,4-oxadiazoles, Antifungal activity, Antiplasmodial activity
DOI: https://doi.org/10.31838/ijpr/2021.13.02.041
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