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Synthesis and Evaluation of Some New Quinoline Based 1, 3, 4-Oxadiazoles as Potential Antimicrobial and Antimalarial Agents
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| Author:
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HEMALATHA GADEGONI, SARANGAPANI MANDA, SHIVAPRASAD RANGU, SYEDA NISHAT FATHIMA
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| Abstract:
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A series of novel 2-(5-penyl-[1,3,4]oxadiazol-2-yl)-quinolines (5a-g) from benzoic acid N'-(quinoline-2-
carbonyl)-hydrazides (4a-g) were synthesized in good yields by involving quinoline-2-carboxylic acid (1) as
raw material and quinoline-2-carbonyl chloride (2) and quinoline-2-carboxylic acid hydrazide (3) as reactive
intermediates. The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H
NMR and Mass spectral data. Further, all the compounds were screened for their antifungal and antiplasmodial
activity.
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| Keyword:
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Qinolino-1,3,4-oxadiazoles, Antifungal activity, Antiplasmodial activity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.041
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| Download:
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Request For Article
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