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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Effect of Guava (Psidium guajava L) Fruit Extract on Pulmonary Tissue and Malondialdehyde Levels of Rat (Rattus norvegicus) Exposed to Cigarette Smoke

Author: DEWA KETUT MELES, WURLINA WURLINA, IMAM MUSTOFA, MENTARI RACHMAWATI, NILUH SUWASANTI, DESAK KETUT SEKAR CEMPAKA PUTRI
Abstract: Cigarette smoke contains various harmful compounds for pulmonary tissue due to oxidative stress. Meanwhile, guava (Psidium guajava L) fruit contains high antioxidants such as quercetin and vitamin C. This study aimed to determine the effect of guava fruit extract on rat exposed cigarette smoke on pulmonary tissue as a model. The 50 healthy female rats (Rattus norvegicus, Wistar strain) were randomly divided into five groups. The control group and T0 groups were administered with carboxymethyl cellulose 0.5%; meanwhile, T1, T2, and T3 groups were administered with guava fruit extract 3.78, 2x3.78, and 3x3.78 mg/200 grams body weight/day. Administration of carboxymethyl cellulose and guava fruit extract were conducted in a volume of 0.5 ml daily for 44 days using a stomach tube. Furthermore, all rats, except the control group, were exposed to electric cigarette smoke with pure tobacco on days 15-44 in 20 suction daily. On day 45, all rats were terminated to examine the histopathological pulmonary cells and serum malondialdehyde levels. Statistic analysis using one-way ANOVA followed by the least significant difference test at a 95% level of significance The result showed that guava fruit extract administration could be repairing pulmonary tissue damaged due to cigarette smoke exposure. It was indicated by reducing the alveolar congestion, alveolar septum thickening, reducing apoptotic and necrotic of alveolar cells, and reducing serum malondialdehyde levels. This study concluded that the administration of guava fruit extract was compensated for the negative effect of cigarette smoke on rats' pulmonary tissue.
Keyword: Alveolar septum, antioxidant, apoptosis, congestion, malondialdehyde, necrosis.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.130
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