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IL-18, Adiponectin and Metabolic Parameters in Obese Adolescents
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| Author:
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ROEDI IRAWAN, NUR AISIYAH WIDJAJA, META HERDIANA HANINDITA, RENDI AJI PRIHANINGTYAS
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| Abstract:
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Background: The prevalence of obesity in adolescents in developing countries is increasing. Obesity causes
an imbalance of cytokines, which causes inflammation that triggers metabolic disorders. Early biomarkers
associated with metabolic complications in obese adolescents need to be assessed, but this is limited in
developing countries.
Purpose: To analyze the correlation between IL-18 and adiponectin, fasting blood glucose, insulin and lipid
profile levels in obese adolescents
Methods: This was a cross-sectional study conducted on 59 obese adolescents. Obesity was established if the
body mass index (BMI) was higher than the 95th percentile according to age and gender, based on the Centers
for Disease Control growth charts. Blood tests performed on the subjects included IL-18, adiponectin, lipid
profiles (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides), insulin and fasting blood
glucose levels. Both IL-18 and adiponectin were measured using enzyme-linked immunosorbent assay. Data
were analysed with correlation tests and regression using SPSS software
Results: In this study, the mean IL-18 level was 0.777 ± 0.825. IL-18 was not correlated with adiponectin,
blood glucose, insulin or lipid profiles (p > 0.05) but it was correlated with HDL-cholesterol levels (p = 0.036; r
= -0.274).
Conclusion: IL-18 was negatively correlated with HDL-cholesterol levels, with a regression model of HDL =
64.367-25.649(IL-18). IL-18 can thus be used as a potential marker for predicting metabolic complications
associated with obesity in obese adolescents.
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| Keyword:
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Obesity; Adolescents; IL-18; Adiponectin; Metabolic parameters
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.129
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| Download:
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