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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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IL-18, Adiponectin and Metabolic Parameters in Obese Adolescents

Author: ROEDI IRAWAN, NUR AISIYAH WIDJAJA, META HERDIANA HANINDITA, RENDI AJI PRIHANINGTYAS
Abstract: Background: The prevalence of obesity in adolescents in developing countries is increasing. Obesity causes an imbalance of cytokines, which causes inflammation that triggers metabolic disorders. Early biomarkers associated with metabolic complications in obese adolescents need to be assessed, but this is limited in developing countries. Purpose: To analyze the correlation between IL-18 and adiponectin, fasting blood glucose, insulin and lipid profile levels in obese adolescents Methods: This was a cross-sectional study conducted on 59 obese adolescents. Obesity was established if the body mass index (BMI) was higher than the 95th percentile according to age and gender, based on the Centers for Disease Control growth charts. Blood tests performed on the subjects included IL-18, adiponectin, lipid profiles (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides), insulin and fasting blood glucose levels. Both IL-18 and adiponectin were measured using enzyme-linked immunosorbent assay. Data were analysed with correlation tests and regression using SPSS software Results: In this study, the mean IL-18 level was 0.777 ± 0.825. IL-18 was not correlated with adiponectin, blood glucose, insulin or lipid profiles (p > 0.05) but it was correlated with HDL-cholesterol levels (p = 0.036; r = -0.274). Conclusion: IL-18 was negatively correlated with HDL-cholesterol levels, with a regression model of HDL = 64.367-25.649(IL-18). IL-18 can thus be used as a potential marker for predicting metabolic complications associated with obesity in obese adolescents.
Keyword: Obesity; Adolescents; IL-18; Adiponectin; Metabolic parameters
DOI: https://doi.org/10.31838/ijpr/2021.13.02.129
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