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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antidiabetic Activity of Lansau Herb Extract in Glucose Induced Diabetic Male Rats

Author: RUSLIN , HENNY KASMAWATI, SUNANDAR IHSAN, SURYANI, MUHAMMAD ARBA, NUR RAHMADHANI A. SIDA, NASAR
Abstract: Lansau is a traditional folk medicine of the Muna tribe, which consists of 44 medicinal plants. Lansau has been used to overcome metabolic diseases such as diabetes mellitus. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. It is characterized by a progressive change in the histopathological structure of the pancreatic Langerhans islets. This study aims to determine the effect of ethanol extract of Lansau concoction on blood-glucose-lowering and the histopathological changes of the pancreas in glucose-induced male Wistar rats. Rats were divided into six treatment groups, the normal controls group, the positive control group (K (+)), the negative control group (K (-)), the dose group 6.907 mg/kg BW(LS I), the dose group 13.814 mg/kg BW (LS II), and the dose group 27.628 mg/kg BW (LS III). The results showed that the ethanol extract of lansau reduced the fasting blood glucose levels of diabetic rats, and repaired endocrine cells' morphology on Langerhans islands. The dose of Lansau showed a decrease in fasting blood glucose levels, and a repair in the morphology of the pancreatic Langerhans islets was 13.814 mg/kg BW
Keyword: Diabetes Mellitus, Lansau, Glucose induction, Diabetic Rats, Pancreatic histopathology
DOI: https://doi.org/10.31838/ijpr/2021.13.02.094
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