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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Inflammation mediated wound healing efficacy of Chloroxylon swietenia DC. fruit phytocompounds.

Author: , RAVISHANKARA B, RIAZ MAHMOOD, V KRISHNA, VINAYKUMAR NM, RAVIKUMAR S
Abstract: Chloroxylon swietenia is a medicinal plant used in folklore remedies to treat wounds, cuts, burns, and skin diseases for quick relief and also used for wounds infected with animal worms, fungal skin infections, and rheumatism, etc. The present aim is to appraise the anti-inflammatory and wound healing efficacy of Chloroxylon swietenia fruit phytocompounds and to authenticate its traditional claims. This study was designed using protein denaturation methods and rat wound models. Among selected fruit extracts, the fruit ethanol extract offered significant inhibition of BSA (Bovine serum album) denaturation with IC50=201.05µg/ml and HRBC (Human red blood cell) membrane lysis with IC50 132.94µg/ml. The fruit ethanol extract exhibited prominent results i.e. healing the lesion within day 14 in the excision wound model. Also showed better wound breaking strength(WBS) of 766.88 ± 3.95g which is comparatively closer to the standard povidone-iodine (813.24±2.51g) treatment in the incision wound model. Conclusively, the increased fruit ethanol extract exhibited early epithelisation, enhanced wound contraction, increased WBS, and superior skin collagen tissue development. The wound healing potential was further indicated by downregulation of free radicals and inflammatory markers associated with enhanced antioxidants of wet granulation tissue and biochemical markers of dry granulation tissue shown to be up-regulated in a dead space wound model. The current study might establish Chloroxylon swietenia as a good source of therapeutic wound healing drugs with anti-inflammatory and antioxidant potentials.
Keyword: Chloroxylon swietenia, Anti-inflammatory, Hydroxyproline, Free radicals.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.203
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