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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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New analysis with a comparative study for antihistaminic Levocetirizine di-HCl in Levcet dosage form, human fluids plasma/urine with modified carbon paste sensor

Author: AMAL F. KHORSHID, MARWA FOUAD, EHAB ELKADY, MENNAT ALLAH M.SALEM, AMANY MORSI
Abstract: A novel, simple, rapid, selective, cheap and sensitive potentiometric method is constructed for determination of levoceterizine cation (LC+). Sensors are constructed based on ion-associations (LC+) with silicomolybdic acid [H4Mo12O40] (SMA) (sensor 1) and with phosphomolybdic acid [H3Mo12O40] (PMA) (sensor 2) with solvent mediator tricresyl phathalate (TCP). An excellent sensors behavior including Nernstian slopes 59.0±0.2 and 60.1±0.5 mV per decade at 25 ºC with the concentration ranges from 5×10-6- 1×10-2 and 1×10-6- 1.0×10-2 and detection limits 1x10-6, 2.25x10-7 mol/L for sensors 1, 2 respectively,. The effect of composition, response time, pH, different some inorganic cations, organic, protein interference and temperature are studied. (CMCPS) has a performance characteristic of high stability, short response time, selectivity, accuracy, low detection limit, high reproducibility, precision and low cost. Sensors applications for determination of LC+ in bulk powder, Levcet dosage form, biological human fluids (plasma/ spiked urine) are taken from a healthy volunteer and for the monitoring Levcet tablets in vitro dissolution rates are also studied. (CMCPS) exhibit excellent behaviors and satisfactory recovery between the results of the proposed method and from the pharmacopeia method.
Keyword: levocetirzine di-HCl, chemical modified carbon paste sensor (CMCPS), potentiometry, Levcet tablets, human fluids, Vitro-dissolution rates.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.197
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