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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Title of the article: Effect of chronic periodontitis on systemic inflammation – A cross sectional study

Author: DR. SELVAKUMAR JAYARAMAN, DR. JAIDEEP MAHENDRA, DR. LITTLE MAHENDRA, DR.SRUTHI SRINIVASAN
Abstract: Background: Periodontal infection and local inflammation have been implicated as a possible cause for various systemic ailments and conditions. The mechanisms proposed is the increase in systemic inflammation by the periodontal disease. Objective: Our objective was to investigate any relationship between periodontitis and systemic inflammation by assessing the plasma fibrinogen levels, total white blood cell and neutrophil counts in patients with localized and generalized chronic periodontitis and compare these values with the controls. Design: The study is cross sectional pilot study. Patients and Methods: Group – I (chronic localized periodontitis), Group – II (Generalized chronic periodontitis) and Group – III (healthy controls). The study had the approval of the institutional ethics committee and a written informed consent was obtained from all participating persons. The periodontal status was evaluated by measuring the pocket depth and clinical attachment level. Peripheral venous blood was sampled for biochemical evaluation of plasma fibrinogen level, total leucocyte and neutrophil counts. Main Outcome measures: The main outcome measure expected from the study was a significant difference in the parameters between the periodontitis groups and control groups. Sample size: The study consisted of 45 subjects aged 30 – 50 years who were divided into three groups of 15 subjects each. Results: Fibrinogen levels were significantly higher in the periodontitis groups compared to the controls. Generalized chronic periodontitis lead to significant increased counts of total leucocytes and neutrophils than healthy controls while no significant difference was observed in when localized periodontitis patients were compared to healthy controls. Probing pocket depth and clinical attachment level was found to be higher in generalized chronic periodontitis as compared to other groups. Conclusion: We concluded that the higher extent of severe periodontal disease may pose a risk for systemic inflammation and its control should be one of the main components in the treatment plan of persons with systemic diseases. Limitations: The study described here is a pilot study with a limited sample size.
Keyword: Chronic Periodontitis, Plasma fibrinogen Levels, White Blood cell, Neutrophils, Inflammation, Systemic diseases.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.105
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