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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Nanoparticulates as Controlled and Targeted Drug Delivery: An Overview

Author: UPLOADED BY-ADMIN, S L HARIKUMAR, GURJEET KAUR
Abstract: Nanotechnology has emerged as one of the very promising fields of biomedical research in the last few decades. Drug delivery is one of the areas where this technology has made remarkable progress. The present article is an attempt to present the brief history of nanotechnology and market forecasts about nanotechnology. The article presents the absorption mechanism, drug targeting, nanotechnology based systems and method of preparation of nanoparticulates. Nano biosystems research is a priority in many countries and its relevance within nanotechnology is expected to increase in the future. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. There has been a considerable research interest in the area of developing drug delivery using nanoparticles (NP’s) as carriers for small and large molecules. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of drug delivery system. They have been used in-vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to this site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing the side-effects. This review article presents the most outstanding contributions in the field of nanotechnology as drug delivery system, pharmaceutical nanotechnology based systems, methods of preparation, applications, advantages and disadvantages.
Keyword: Nanotechnology, Nanoparticles, Nano-systems, Nanodevices, Nanotubes, targeted and controlled drug
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