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Nanoparticulates as Controlled and Targeted Drug Delivery: An Overview
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UPLOADED BY-ADMIN, S L HARIKUMAR, GURJEET KAUR
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| Abstract:
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Nanotechnology has emerged as one of the very promising fields of biomedical research in the last few decades. Drug
delivery is one of the areas where this technology has made remarkable progress. The present article is an attempt to present
the brief history of nanotechnology and market forecasts about nanotechnology. The article presents the absorption
mechanism, drug targeting, nanotechnology based systems and method of preparation of nanoparticulates. Nano biosystems
research is a priority in many countries and its relevance within nanotechnology is expected to increase in the future.
The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate and therefore
enhances bioavailability. There has been a considerable research interest in the area of developing drug delivery using
nanoparticles (NP’s) as carriers for small and large molecules. Targeting delivery of drugs to the diseased lesions is one of
the most important aspects of drug delivery system. They have been used in-vivo to protect the drug entity in the systemic
circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to this site
of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase
therapeutic benefit, while minimizing the side-effects. This review article presents the most outstanding contributions in the
field of nanotechnology as drug delivery system, pharmaceutical nanotechnology based systems, methods of preparation,
applications, advantages and disadvantages.
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| Keyword:
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Nanotechnology, Nanoparticles, Nano-systems, Nanodevices, Nanotubes, targeted and controlled drug
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Request For Article
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