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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Molecular Docking and In-Vitro Studies of Some New Oxadiazole Derivatives for Antidiabetic Properties

Author: DR JADHAV SHAILAJA BHANUDAS, SALVE MEGHA TUKARAM
Abstract: In this research, we explain first of all drug receptor interaction by molecular modeling. In the present analysis, 14 oxadizole derivatives containing 2-cyano pyrrolidine sulfonamide substituents were synthesized and structural elucidation study compound characterization was tested for their in vitro dpp-4 inhibitor as an antidiabetic properties compound A-III was found to be a potent DPP-4 inhibitor at conc 10 um concentration To standard vildagliptin. Both compounds have been subjected to molecular docking studies for inhibition of the DPP-4 enzyme. In molecular docking studies, all synthesis compounds with reduced binding energy and strong affinity to the active pocket have been shown to be as good Dpp-4 inhibitors as antidiabetic properties.
Keyword: Type 2 diabetes (T2D), sulfonamide derivatives of 2-cyanopyrrolidine,molecular docking.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.138
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