IJPR  articles are Indexed in SCOPUS (2010 - 2021)Click Here     *Five Years Citation in Google scholar (2016 - 2020) is. 1451*        Now IJPR is Q2 in SJR Ranking     Scopus Coverage of IJPR (2010-2021 Issue 1)            

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Analytical Method Development and Validation of Axitinib by RP-HPLC Method

Author: M BHARGAVA SAI, CHANDAN R S, BARATH M, DEVI SHRI CHIRIKI, ANAND KUMAR TENGLI
Abstract: Axitinib is a tyrosine kinase inhibitor of the second generation that selectively inhibits the endothelial vascular growth factor. Axitinib inhibits angiogenesis, tumour progression and metastases by this mechanism of action. It is stated that the strength of the first-generation VEGFR inhibitors is 50-450 times higher. Axitinib is a byproduct of indazole. These are most often sold using the name Inlyta as oral formulations. Therefore, an accurate, fast, simple and cost-effective RP-HPLC technique for detecting Axitinib was developed. The RPHPLC method is developed by using 0.1 % Formic acid in MeOH and ACN 80:20 v/v as MP, the Flow rate is maintained at 1 mL/minute. The column used for the analysis was Phenomenex luna C18 column (250mm X4.60 mm 5µ) and the column oven temperature was maintained at 25 ºC. Detection of Axitinib was performed by using a UV detector at 255nm. The linearity range was 1- 32 µg/ml and the correlation coefficient was found to be 0.9956. By this proposed method RT of Axitinib was identified at 2.6 min. The validation of the method concerning system suitability, linearity, accuracy, precision, robustness and ruggedness according to ICH guidelines.
Keyword: UV detector, RP-HPLC method, Axitinib, ICH Guidelines.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.125
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free